Self-adaptive Controllers for Renewable Energy Communities Based on Transformer Loading Estimation

In this paper, self-adaptive controllers for renewable energy communities based on data-driven approach are proposed to mitigate the voltage rise and transformer congestion at the community level. In the proposed approach, the transformer loading percentage is estimated by the trained data-driven model, which uses the extreme gradient boosting regression algorithm based on a measurement set acquired from critical coupling points of the communities. To avoid voltage rise issues, the droop control parameters (i.e., voltage threshold for P - V, Q - V curves) are adaptively tuned based on the solar irradiance availability and estimated transformer loading. The proposed approach has been tested in the IEEE European LV distribution network. Results showed that the control approach could effectively reduce 22.2 % of the total overloaded instances, while still keeping voltage magnitude in the operation range. This method can help DSOs manage voltage violation and congestion without further communication

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors.

Purpose:To evaluate the safety, recommended phase II dose (RP2D) and efficacy of pexidartinib, a colony stimulating factor receptor 1 (CSF-1R) inhibitor, in combination with weekly paclitaxel in patients with advanced solid tumors. Patients and Methods:In part 1 of this phase Ib study, 24 patients with advanced solid tumors received escalating doses of pexidartinib with weekly paclitaxel (80 mg/m2). Pexidartinib was administered at 600 mg/day in cohort 1. For subsequent cohorts, the dose was increased by ⩽50% using a standard 3+3 design. In part 2, 30 patients with metastatic solid tumors were enrolled to examine safety, tolerability and efficacy of the RP2D. Pharmacokinetics and biomarkers were also assessed. Results:A total of 51 patients reported ≥1 adverse event(s) (AEs) that were at least possibly related to either study drug. Grade 3-4 AEs, including anemia (26%), neutropenia (22%), lymphopenia (19%), fatigue (15%), and hypertension (11%), were recorded in 38 patients (70%). In part 1, no maximum tolerated dose was achieved and 1600 mg/day was determined to be the RP2D. Of 38 patients evaluable for efficacy, 1 (3%) had complete response, 5 (13%) partial response, 13 (34%) stable disease, and 17 (45%) progressive disease. No drug-drug interactions were found. Plasma CSF-1 levels increased 1.6- to 53-fold, and CD14dim/CD16+ monocyte levels decreased by 57-100%. Conclusions:The combination of pexidartinib and paclitaxel was generally well tolerated. RP2D for pexidartinib was 1600 mg/day. Pexidartinib blocked CSF-1R signaling, indicating potential for mitigating macrophage tumor infiltration

Cosine Similarity Measures of Bipolar Neutrosophic Set for Diagnosis of Bipolar Disorder Diseases

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Similarity plays a significant implicit or explicit role in various fields. In some real applications in decision making, similarity may bring counterintuitive outcomes from the decision maker’s standpoint. Therefore, in this research, we propose some novel similarity measures for bipolar and interval-valued bipolar neutrosophic set such as the cosine similarity measures and weighted cosine similarity measures. The propositions of these similarity measures are examined, and two multi-attribute decision making techniques are presented based on proposed measures. For verifying the feasibility of proposed measures, two numerical examples are presented in comparison with the related methods for demonstrating the practicality of the proposed method. Finally, we applied the proposed measures of similarity for diagnosing bipolar disorder diseases

An overview of grid-edge control with the digital transformation

Distribution networks are evolving to become more responsive with increasing integration of distributed energy resources (DERs) and digital transformation at the grid edges. This evolution imposes many challenges to the operation of the network, which then calls for new control and operation paradigms. Among others, a so-called grid-edge control is emerging to harmonise the coexistence of the grid control system and DER’s autonomous control. This paper provides a comprehensive overview of the grid-edge control with various control architectures, layers, and strategies. The challenges and opportunities for such an approach at the grid edge with the integration of DERs and digital transformation are summarised. The potential solutions to support the network operation by using the inherent controllability of DER and the availability of the digital transformation at the grid edges are discussed

VaporSPOT: Parallel Synthesis of Oligosaccharides on Membranes

Automated chemical synthesis has revolutionized synthetic access to biopolymers in terms of simplicity and speed. While automated oligosaccharide synthesis has become faster and more versatile, the parallel synthesis of oligosaccharides is not yet possible. Here, a chemical vapor glycosylation strategy (VaporSPOT) is described that enables the simultaneous synthesis of oligosaccharides on a cellulose membrane solid support. Different linkers allow for flexible and straightforward cleavage, purification, and characterization of the target oligosaccharides. This method is the basis for the development of parallel automated glycan synthesis platforms

STABILIZATION OF NON ISOTHERMAL CHEMICAL REACTORS USING TWO THERMODYNAMIC LYAPUNOV FUNCTIONS

The main goal of this paper is to introduce a link between the thermodynamics and control systems theory. More precisely, the paper focuses on Lyapunov based control of process systems, specially the non isothermal Continuous Stirred Tank Reactors in a thermodynamic framework, using either the jacket temperature or the inlet molar flow rate as the only control input. As soon as the constraint on the total mass is considered and the reaction kinetics is a Lipschitz continuous function with respect to the temperature, it shows that the stabilization of thermal solicitations reciprocally entails the one of matter using La Salle’s invariance principle. As a consequence, these control problems can be solved if the closed loop Lyapunov functions are chosen to be proportional to the thermal part or material part of the so called thermodynamic availability function. Some numerical simulations for a first order chemical reaction with multiple steady states are given to validate our theoretical developments. The performance of the obtained nonlinear controllers with regard to the conversion rate is also discussed.The main goal of this paper is to introduce a link between the thermodynamics and control systems theory. More precisely, the paper focuses on Lyapunov based control of process systems, specially the non isothermal Continuous Stirred Tank Reactors in a thermodynamic framework, using either the jacket temperature or the inlet molar flow rate as the only control input. As soon as the constraint on the total mass is considered and the reaction kinetics is a Lipschitz continuous function with respect to the temperature, it shows that the stabilization of thermal solicitations reciprocally entails the one of matter using La Salle’s invariance principle. As a consequence, these control problems can be solved if the closed loop Lyapunov functions are chosen to be proportional to the thermal part or material part of the so called thermodynamic availability function. Some numerical simulations for a first order chemical reaction with multiple steady states are given to validate our theoretical developments. The performance of the obtained nonlinear controllers with regard to the conversion rate is also discussed

Conjugated polyelectrolyte hole transport layer for inverted-type perovskite solar cells

Organic-inorganic hybrid perovskite materials offer the potential for realization of low-cost and flexible next-generation solar cells fabricated by low-temperature solution processing. Although efficiencies of perovskite solar cells have dramatically improved up to 19% within the past 5 years, there is still considerable room for further improvement in device efficiency and stability through development of novel materials and device architectures. Here we demonstrate that inverted-type perovskite solar cells with pH-neutral and low-temperature solution-processable conjugated polyelectrolyte as the hole transport layer (instead of acidic PEDOT:PSS) exhibit a device efficiency of over 12% and improved device stability in air. As an alternative to PEDOT: PSS, this work is the first report on the use of an organic hole transport material that enables the formation of uniform perovskite films with complete surface coverage and the demonstration of efficient, stable perovskite/fullerene planar heterojunction solar cellsopen4

Glycoside hydrolase from the GH76 family indicates that marine Salegentibacter sp. Hel_I_6 consumes alpha-mannan from fungi

Microbial glycan degradation is essential to global carbon cycling. The marine bacterium Salegentibacter sp. Hel_I_6 (Bacteroidota) isolated from seawater off Helgoland island (North Sea) contains an α-mannan inducible gene cluster with a GH76 family endo-α-1,6-mannanase (ShGH76). This cluster is related to genetic loci employed by human gut bacteria to digest fungal α-mannan. Metagenomes from the Hel_I_6 isolation site revealed increasing GH76 gene frequencies in free-living bacteria during microalgae blooms, suggesting degradation of α-1,6-mannans from fungi. Recombinant ShGH76 protein activity assays with yeast α-mannan and synthetic oligomannans showed endo-α-1,6-mannanase activity. Resolved structures of apo-ShGH76 (2.0 Å) and of mutants co-crystalized with fungal mannan-mimicking α-1,6-mannotetrose (1.90 Å) and α-1,6-mannotriose (1.47 Å) retained the canonical (α/α)6 fold, despite low identities with sequences of known GH76 structures (GH76s from gut bacteria: <27%). The apo-form active site differed from those known from gut bacteria, and co-crystallizations revealed a kinked oligomannan conformation. Co-crystallizations also revealed precise molecular-scale interactions of ShGH76 with fungal mannan-mimicking oligomannans, indicating adaptation to this particular type of substrate. Our data hence suggest presence of yet unknown fungal α-1,6-mannans in marine ecosystems, in particular during microalgal blooms

Genome-wide association mapping for root traits in a panel of rice accessions from Vietnam

Background: Despite recent sequencing efforts, local genetic resources remain underexploited, even though they carry alleles that can bring agronomic benefits. Taking advantage of the recent genotyping with 22,000 single-nucleotide polymorphism markers of a core collection of 180 Vietnamese rice varieties originating from provinces from North to South Vietnam and from different agrosystems characterized by contrasted water regimes, we have performed a genome-wide association study for different root parameters. Roots contribute to water stress avoidance and are a still underexploited target for breeding purpose due to the difficulty to observe them. Results: The panel of 180 rice varieties was phenotyped under greenhouse conditions for several root traits in an experimental design with 3 replicates. The phenotyping system consisted of long plastic bags that were filled with sand and supplemented with fertilizer. Root length, root mass in different layers, root thickness, and the number of crown roots, as well as several derived root parameters and shoot traits, were recorded. The results were submitted to association mapping using a mixed model involving structure and kinship to enable the identification of significant associations. The analyses were conducted successively on the whole panel and on its indica (115 accessions) and japonica (64 accessions) subcomponents. The two associations with the highest significance were for root thickness on chromosome 2 and for crown root number on chromosome 11. No common associations were detected between the indica and japonica subpanels, probably because of the polymorphism repartition between the subspecies. Based on orthology with Arabidopsis, the possible candidate genes underlying the quantitative trait loci are reviewed. Conclusions: Some of the major quantitative trait loci we detected through this genome-wide association study contain promising candidate genes encoding regulatory elements of known key regulators of root formation and development